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Related Experiment Videos

Tissue factor on the loose.

P L Giesen1, Y Nemerson

  • 1Synapse B.V. at Maastricht University, The Netherlands. P.Giesen@thrombin.com

Seminars in Thrombosis and Hemostasis
|November 25, 2000
PubMed
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Tissue factor (TF) initiates blood coagulation. New evidence shows circulating TF, not just arterial wall TF, plays a major role in arterial thrombosis, a leading cause of death.

Area of Science:

  • Hematology
  • Vascular Biology
  • Biochemistry

Background:

  • Arterial thrombosis, a major cause of death, is traditionally linked to tissue factor (TF) in pathologically altered artery walls.
  • The classical view posits TF within the artery wall initiates coagulation and subsequent thrombosis.

Purpose of the Study:

  • To review evidence challenging the classical view of thrombosis initiation.
  • To investigate the role of extracellular, encrypted, and plasma-borne TF in thrombosis.

Main Methods:

  • Review of existing literature on TF expression and activity.
  • In vitro studies of TF expression in stimulated cells and extracellular matrix.
  • Ex vivo perfusion studies using collagen-coated slides.
  • In vivo thrombosis models involving injured rat aorta.

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Main Results:

  • TF is expressed in various cells and extracellular matrices, and can exist in encrypted or latent forms.
  • TF activity is present in native blood and plasma, and its inhibition prevents thrombus formation in vitro.
  • Extracellular TF is found on the intimal surface of injured aorta, with all measurable activity being extracellular.

Conclusions:

  • Blood-borne TF significantly contributes to arterial thrombosis.
  • TF encryption may serve as a protective mechanism against thrombosis.
  • Circulating TF might be active below the threshold for initiating coagulation.