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Related Experiment Videos

Endogenous lectins as cell surface transducers.

E Hébert1

  • 1Glycobiologie, Vectorologie et Trafic Intracellulaire, Centre de Biophysique Moléculaire, UPR No. 4301 du CNRS, Orléans, France. hebert@cnrs-orleans.fr

Bioscience Reports
|November 25, 2000
PubMed
Summary
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Animal lectins, carbohydrate-binding proteins, mediate cell signaling by binding to glycoconjugates. These lectin-like receptors initiate "outside-in" signaling, influencing cellular events and offering novel transduction pathways.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Cell-surface receptors and ligands mediate cell-cell and cell-substratum interactions.
  • Animal lectins, a class of carbohydrate-binding proteins, interact with cell-surface glycoconjugates.
  • These interactions are crucial for various biological processes.

Purpose of the Study:

  • To review recent advances in understanding the molecular basis of "outside-in" signaling mediated by lectins.
  • To highlight the role of lectin-like receptors in signal transduction.
  • To explore the potential of lectins as alternative or additional cell surface transducers.

Main Methods:

  • Literature review focusing on recent advances in lectin-mediated signaling.
  • Analysis of molecular mechanisms of lectin-like receptor signal transduction.

Related Experiment Videos

  • Comparison of lectin signaling pathways with growth factor receptor signaling.

    • Main Results:

    • Lectin-like receptors mediate "outside-in" signaling by binding to glycoconjugates.
    • These receptors mimic growth factor receptor functions, coupling to tyrosine kinases or G proteins.
    • Lectin-like receptors can induce novel signal transduction mechanisms and intracellular events.

    Conclusions:

    • Surface lectins act as crucial transducers of extracellular information into the cell.
    • Lectin-mediated signaling pathways offer alternative or additional signaling potentials compared to growth factor receptors.
    • Further research into lectin signaling may reveal new therapeutic targets.