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Conformationally locked nucleosides. Synthesis of oligodeoxynucleotides containing
1Chemistry Laboratory, ICN Pharmaceuticals, Inc, Costa Mesa, California 92626, USA.
Nucleosides, Nucleotides & Nucleic Acids
|November 25, 2000
Abstract:
3'-Amino-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-N,5'(R)-C-ethylenethymidine (6) was synthesized starting from 3'-azido-3'-deoxythymidine. Condensation of 6 with 5'O-(H-phosphonyl)thymidine and 5'-O-(p-nitrophenoxycarbonyl)thymidine derivatives gave dinucleotide and dinucleoside derivatives, respectively, which were incorporated into oligodeoxynucleotides (ODNs). Tm data of the modified ODNs are also presented.