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Related Experiment Videos

Rutin inhibits ovariectomy-induced osteopenia in rats.

M N Horcajada-Molteni1, V Crespy, V Coxam

  • 1Unité Maladies Métaboliques et Micronutriments, Institut National de la Recherche Agronomique, Clermont-Theix, France.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
|November 25, 2000
PubMed
Summary

Rutin supplementation prevented bone loss in ovariectomized rats by reducing bone resorption and increasing bone formation. This polyphenol shows potential for treating osteopenia without adverse effects on uterine weight.

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Area of Science:

  • Biochemistry
  • Pharmacology
  • Orthopedics

Background:

  • Osteopenia is a growing concern, with polyphenols showing promise for bone protection.
  • Ovariectomy (OVX) in rats is a common model for postmenopausal bone loss.

Purpose of the Study:

  • To investigate the effects of rutin on bone metabolism in ovariectomized (OVX) rats.
  • To assess rutin's impact on bone mineral density, strength, and markers of bone turnover.

Main Methods:

  • Thirty Wistar rats were divided into sham-operated (SH), OVX, and OVX + rutin (OVX + R) groups.
  • Rutin (0.25%) was administered orally to the OVX + R group for 90 days.
  • Bone mineral density, femoral failure load, urinary deoxypyridinoline (DPD), calciuria, and plasma osteocalcin (OC) were measured.

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Main Results:

  • Rutin prevented the decrease in femoral mineral density and increased femoral failure load in OVX rats.
  • Rutin reduced urinary DPD excretion and calciuria, indicating decreased bone resorption.
  • Rutin increased plasma osteocalcin levels, suggesting enhanced osteoblastic activity.
  • HPLC analysis confirmed the presence of rutin metabolites (quercetin, isorhamnetin) in plasma.

Conclusions:

  • Rutin effectively inhibits ovariectomy-induced bone loss in rats.
  • Rutin acts by decreasing bone resorption and increasing osteoblastic activity.
  • Rutin demonstrates potential as a therapeutic agent for osteopenia without uterotrophic effects.