Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genomic control of receptor function.

N Burnashev1, A Rozov

  • 1Max-Planck-Institut für medizinische Forschung, Heidelberg, Germany. nail@sunny.mpimf-heidelberg.mpg.de

Cellular and Molecular Life Sciences : CMLS
|November 25, 2000
PubMed
Summary

Ionotropic ligand-gated channels, crucial for synaptic transmission, are regulated by gene families, RNA processing, and subunit interactions. Glutamate receptor channels exemplify how these steps shape synaptic function.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

GABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease.

Nature communications·2018
Same author

Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model.

Nature communications·2014
Same author

Plasma concentrations of key metabolites and insulin in late-pregnant ewes carrying 1 to 5 fetuses.

Journal of animal science·2011
Same author

Treatment of pregnancy toxaemia in sheep with flunixin meglumine.

The Veterinary record·2009
Same author

NMDA receptors trigger neurosecretion of 5-HT within dorsal raphe nucleus of the rat in the absence of action potential firing.

The Journal of physiology·2006
Same author

Carrying the FecB (Booroola) mutation is associated with lower birth weight and slower post-weaning growth rate for lambs, as well as a lighter mature bodyweight for ewes.

Reproduction, fertility, and development·2006

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Ionotropic ligand-gated channels are essential for synaptic transmission in the nervous system.
  • These channels are regulated at multiple genomic levels, influencing their function.

Purpose of the Study:

  • To review the regulatory mechanisms governing ionotropic ligand-gated channel function.
  • To illustrate how gene expression, RNA processing, and protein interactions determine channel properties using glutamate receptors as an example.

Main Methods:

  • Review of existing literature on ionotropic ligand-gated channels.
  • Focus on gene families, alternative splicing, RNA editing, subunit composition, and postsynaptic protein interactions.
  • Case study analysis of glutamate receptor channels.

Main Results:

  • Receptor function is determined by gene family, posttranscriptional RNA alterations (alternative splicing, editing), and subunit composition.
  • Interactions with postsynaptic density proteins regulate channel function and localization.
  • Glutamate receptor channels demonstrate the impact of these regulatory steps on synaptic transmission.

Conclusions:

  • Multiple layers of regulation, from gene to protein interactions, fine-tune ionotropic ligand-gated channel function.
  • Understanding these regulatory steps is key to comprehending synaptic transmission.
  • Glutamate receptors serve as a model for dissecting these complex regulatory pathways.

Related Experiment Videos