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Proton MR spectroscopy of the brain in patients treated with TIPS
M Hamuro1, K Nakamura, T Matsuoka
1Department of Radiology, Osaka City University Medical School, Osaka, Japan.
Purpose:
To evaluate the utility of proton MR spectroscopy (MRS) for the early detection of hepatic encephalopathy (HE) after transjugular intrahepatic portosystemic shunting (TIPS).
Material And Methods:
Six patients, who underwent TIPS for treatment of portal hypertension, were examined by MRS I week before and 1 week after TIPS. They were simultaneously clinically examined for number connection test, blood NH3 level, liver function test and the Fischer ratio.
Result:
Three of 6 patients showed overt HE 1 to 5 weeks after TIPS and the other 3 patients did not show overt HE. The overt HE group showed the larger ratio of the amounts of glutamine and glutamate/myo-inositol (Glx/MI) than that of non-overt HE group (p<0.05).
Conclusion:
The Glx/MI ratio estimated by MRS was useful for early detection of HE after TIPS.