Related Experiment Videos
Reduced iopromide elimination in hemodialysis with cuprophan membranes
F K Matzkies1, H Reinecke, B Tombach
1Department of Medicine, Westfalian Wilhelms University, Münster, Germany.
Insights
Polysulfone membranes enhance iopromide elimination during hemodialysis more effectively than cuprophan membranes, improving contrast medium clearance in patients with chronic renal failure.
Area of Science:
- Nephrology
- Biomaterials Science
- Radiology
Background:
- Contrast media like iopromide are essential in diagnostic imaging but pose challenges for elimination in patients with chronic renal failure.
- Hemodialysis is a critical intervention for managing contrast medium accumulation in these patients.
Purpose of the Study:
- To investigate the impact of different hemodialysis membrane materials on the efficiency of iopromide elimination.
- To compare the performance of cuprophan and polysulfone membranes in clearing iopromide from plasma.
Main Methods:
- A study involving twenty stable chronic renal failure patients undergoing hemodialysis post-coronary angiography.
- Direct measurement of contrast medium elimination during hemodialysis sessions.
Main Results:
- Polysulfone membranes demonstrated significantly higher iopromide clearance (153 +/- 4 mg/ml) compared to cuprophan membranes (102 +/- 7 mg/ml).
- Elimination half-time was shorter with polysulfone (79 +/- 3 min) versus cuprophan (94 +/- 5 min) membranes.
- Reduced 24-hour urinary iopromide excretion was observed with polysulfone membranes (26 +/- 4 g/24 h) compared to cuprophan (32 +/- 7 g/24 h).
Conclusions:
- Hemodialysis using polysulfone membranes is a more effective strategy for iopromide elimination than using cuprophan membranes.
- The choice of membrane material significantly influences the efficiency of contrast medium removal in renal failure patients.
Purpose:
To evaluate the influence of different membrane materials on the efficiency of iopromide elimination.
Material And Methods:
Twenty stable patients with chronic renal failure after coronary angiography were investigated for contrast medium elimination during hemodialysis directly after contrast medium application.
Results:
Clearance during hemodialysis with cuprophan membranes was 102 +/- 7 mg/ml in contrast to 153 +/- 4 mg/ml in polysulfone membranes. Elimination half-time was 94 +/- 5 min in cuprophan and 79 +/- 3 min in polysulfone membranes, and the elimination rate after 120 min was 59 +/- 2% and 66 +/- 1.5% respectively. Plasma clearance of iopromide was elevated in polysulfone membranes (188 +/-17 ml/min); however, not significantly different to cuprophane membranes (153 +/-11 ml/min). Accordingly, 24-h urinary iopromide excretion was reduced to 26 +/- 4 g/24 h vs. 32 +/- 7 g/24 h.
Conclusion:
Hemodialysis for iopromide elimination with polysulfone membranes is more effective than with cuprophan membranes.