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How do we manage chronic pain?

H G Schaible1, H Vanegas

  • 1Department of Physiology, University of Jena, Teichgraben 8, 07740 Jena, Germany.

Bailliere'S Best Practice & Research. Clinical Rheumatology
|November 28, 2000
PubMed
Summary
This summary is machine-generated.

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This chapter explores pain mechanisms, focusing on how neuronal sensitization contributes to inflammatory pain. It also reviews current drug treatments and future options for managing chronic pain effectively.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Pain Management

Background:

  • Pain is a key symptom of acute damage and chronic inflammatory conditions like rheumatoid arthritis.
  • Neuronal sensitization in peripheral and central nervous systems is crucial for inflammatory pain.
  • Chronic pain involves neurobiological processes and psychological/social factors.

Purpose of the Study:

  • To summarize neuronal mechanisms underlying inflammatory pain.
  • To present current drug treatment principles within neurobiological frameworks.
  • To discuss future therapeutic options and the role of physical/psychosocial therapy.

Main Methods:

  • Review of neuroanatomy, neurophysiology, and neuropharmacology of pain.
  • Analysis of how non-steroidal anti-inflammatory drugs and opioids affect pain mechanisms.

Related Experiment Videos

  • Examination of non-opioidergic and opioidergic analgesic rationale.

    • Main Results:

    • Peripheral and central sensitization of nociceptive neurons are vital for inflammatory pain.
    • Non-steroidal anti-inflammatory drugs and opioids modulate peripheral and central pain pathways.
    • Psychological and social factors significantly influence chronic pain.

    Conclusions:

    • Understanding neuronal sensitization is key to managing inflammatory pain.
    • Current treatments involve modulating pain pathways with various analgesics.
    • Integrated approaches including physical and psychosocial therapies are important for chronic pain management.