New method for accurate prediction of solvent accessibility from protein sequence
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Updated: Oct 10, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
Published on: November 3, 2011
1National Laboratory of Biomacromolecules, Institute of Biophysics, Academia Sinica, Beijing, China.
Abstract:
A novel method was developed for predicting the solvent accessibility. Based on single sequence data, this method achieved 71.5% accuracy with a correlation coefficient of 0.42 in a database of 704 proteins with threshold of 20% for a two-state-defining solvent accessibility. Prediction in a data subset of 341 monomeric proteins achieved 72.7% accuracy with a correlation coefficient of 0. 43. On the average, prediction over short chains gives better results than that over long chains. With a solvent accessibility threshold of 20%, prediction over 236 monomeric proteins with chain length < 300 amino acid residues achieved 75.3% accuracy with a correlation coefficient of 0.44 by jackknife analysis, which is higher than that obtained by previous methods using multiple sequence alignments.
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