Related Experiment Video

Updated: Oct 10, 2026

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
06:46

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring

Published on: December 14, 2020

[Palatophanyngeal mechanism of Gastroesophageal reflux in Pierre-Robin sequence]

Z Dudkiewicz1, E Sekula, W Piwowar

  • 1Klinika Chirurgii Dzieci i Mlodziezy, Instytut Matki i Dziecka, Kasprzaka 17a, 01-211, Warszawa, Poland.

Medycyna Wieku Rozwojowego
|November 28, 2000
PubMed

Insights

Surgical repair of Pierre-Robin sequence effectively treated gastroesophageal reflux (GER) in children. Early intervention improved symptoms, reducing the need for further surgeries.

Area of Science:

  • Pediatric Surgery
  • Gastroenterology
  • Craniofacial Anomalies

Context:

  • Pierre-Robin sequence is associated with gastroesophageal reflux (GER).
  • GER management is crucial for affected children.
  • Surgical interventions for Pierre-Robin sequence may impact GER.

Purpose:

  • To investigate the prevalence of GER in children with Pierre-Robin sequence.
  • To evaluate the efficacy of surgical treatment on GER symptoms.
  • To explore the
  • palatal mechanism
  • of GER in this population.

Summary:

  • Thirty-one children with Pierre-Robin sequence underwent surgical treatment between 1993-1998.
  • Gastroesophageal reflux (GER) was confirmed in 28 cases prior to surgery.
  • Surgical repair (palatoplasty, subperiosteal release of the floor of the mouth, palato-pharyngeal ring repair) led to rapid clinical improvement and early discharge.
  • Post-operative follow-up revealed no GER symptoms.

Impact:

  • Surgical correction of the palato-pharyngeal ring may resolve the "palatal mechanism" causing GER in Pierre-Robin sequence.
  • Early surgical intervention can potentially reduce the need for procedures like glossopexy, gastrostomy, tracheostomy, and Nissen fundoplication.
  • This study highlights a link between craniofacial repair and improved GER management in pediatric patients.

More Related Videos

Surgical Models of Gastroesophageal Reflux with Mice05:19

Surgical Models of Gastroesophageal Reflux with Mice

Published on: August 25, 2015

Minimally Invasive Murine Laryngoscopy for Close-Up Imaging of Laryngeal Motion During Breathing and Swallowing07:45

Minimally Invasive Murine Laryngoscopy for Close-Up Imaging of Laryngeal Motion During Breathing and Swallowing

Published on: December 1, 2023

Related Concept Videos

Gastroesophageal Reflux Disease I: Meaning and Pathophysiology01:29

Gastroesophageal Reflux Disease I: Meaning and Pathophysiology

Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
Gastroesophageal Reflux Disease01:25

Gastroesophageal Reflux Disease

Gastroesophageal reflux disease (GERD) is the backward flow of stomach contents (acid, pepsin, or bile) into the esophagus, causing mucosal inflammation known as esophagitis. It results from failure of antireflux mechanisms, mainly the lower esophageal sphincter (LES), influenced by mechanical and physiological factors.Etiology and Risk FactorsGERD develops when LES function is weakened or when intra-abdominal pressure increases. Risk factors include aging, obesity, and sliding hiatal hernia,...
Physiology of the Gastrointestinal System I: Ingestion and Propulsion01:22

Physiology of the Gastrointestinal System I: Ingestion and Propulsion

The physiology of the gastrointestinal system begins with ingestion as food enters the mouth.
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Esophageal Achalasia01:27

Esophageal Achalasia

Esophageal achalasia is a chronic neurogenic disorder characterized by impaired relaxation of the lower esophageal sphincter (LES) and absent or ineffective peristalsis in the distal esophagus. This leads to a functional obstruction without a physical blockage, despite significant disruption of esophageal motility.EtiologyAchalasia is caused by degeneration of the myenteric (Auerbach's) plexus, specifically the loss of inhibitory ganglion cells that produce vasoactive intestinal peptide (VIP)...
Pathophysiology of Peptic Ulcer Disease: Injurious Factors01:22

Pathophysiology of Peptic Ulcer Disease: Injurious Factors

Peptic ulcers are sores on the stomach's inner lining and the upper small intestine, which are the result of disruptions in the mucosal layer that houses parietal cells which produce gastric acid, and chief cells which secrete pepsinogen.
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds to M3...