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Isolated four-chamber working swine heart model.

E Chinchoy1, C L Soule, A J Houlton

  • 1Department of Anesthesiology, University of Minnesota, Minneapolis, USA.

The Annals of Thoracic Surgery
|November 28, 2000
PubMed
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This study improved an ex vivo swine heart model to simulate human cardiac function. The model maintained physiologic function for up to 240 minutes, aiding research in cardiac responses.

Area of Science:

  • Cardiovascular Physiology
  • Biomedical Engineering
  • Surgical Research

Background:

  • Isolated heart models are crucial for studying cardiac responses independent of systemic influences.
  • Existing models often lack the ability to accurately represent in situ physiologic cardiac function ex vivo.
  • The objective was to develop an ex vivo model that replicates in situ cardiac function.

Purpose of the Study:

  • To develop and validate an ex vivo isolated heart model that accurately simulates human in situ cardiac physiology.
  • To assess the hemodynamic performance and stability of the isolated porcine heart model over time.
  • To provide a platform for studying cardiac responses to various interventions in a controlled environment.

Main Methods:

  • Utilized 12 porcine hearts due to anatomical and physiological similarities to humans.

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  • Designed an apparatus to perfuse all four chambers under simulated in situ conditions with controlled preload and afterload.
  • Conducted hemodynamic characterizations (cardiac output, dP/dt, heart rate) at baseline and at 60, 120, and 240 minutes post-explantation.

    • Main Results:

    • The ex vivo heart model demonstrated functional performance over a 240-minute period.
    • A statistically significant decay in in vitro performance was observed by 240 minutes compared to baseline.
    • The model successfully maintained simulated in situ physiologic conditions for the duration of the experiment.

    Conclusions:

    • An improved protocol for isolating and maintaining ex vivo porcine hearts was established.
    • The model is suitable for studying isolated cardiac responses and hemodynamic function during simulated surgical scenarios.
    • This model offers advantages in representing human cardiac anatomy and physiology, including atrial and ventricular interactions.