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Related Experiment Videos

Luminal and systemic signals trigger intestinal adaptation in the juvenile python.

S M Secor1, E E Whang, J S Lane

  • 1Department of Physiology, School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA. ssecor@olemiss.edu

American Journal of Physiology. Gastrointestinal and Liver Physiology
|November 30, 2000
PubMed
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Juvenile pythons show rapid intestinal adaptation after feeding. Luminal nutrients, not systemic signals, initially drive increased nutrient uptake and intestinal mass in this adaptable python model.

Area of Science:

  • Physiology
  • Gastroenterology
  • Comparative Biology

Background:

  • Juvenile pythons exhibit significant intestinal adaptation post-feeding.
  • The python model offers a unique opportunity to study intestinal adaptation due to ease of surgical manipulation and laboratory maintenance.

Purpose of the Study:

  • To investigate the specific signals and agents responsible for rapid intestinal adaptation in pythons.
  • To differentiate between nutrient-driven and systemically-driven responses in intestinal adaptation.

Main Methods:

  • Surgical isolation of the middle third of the small intestine in pythons, maintaining vascular and nerve supply.
  • Restoration of intestinal continuity via end-to-end anastomosis.
  • Measurement of amino acid and glucose uptake, and intestinal mass at 24 hours and 3 days post-feeding in both reanastomosed and isolated segments.

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Main Results:

  • Reanastomosed intestinal segments (receiving nutrients) showed a 15-fold increase in nutrient uptake and doubled mass within 24 hours.
  • The isolated segment (without luminal nutrients) showed no changes in morphology or nutrient uptake at 24 hours.
  • By 3 days, the isolated segment exhibited upregulated nutrient uptake but lacked morphological changes, unlike the reanastomosed segments.

Conclusions:

  • Luminal nutrients and/or pancreaticobiliary secretions are primary triggers for rapid upregulation of intestinal transporters and mass.
  • Systemic neural or hormonal signals appear to regulate transporter activity later but do not induce the trophic response (mass increase).