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Menstrual-related changes in motoric function in women with Parkinson's disease
K Kompoliti1, C L Comella, J A Jaglin
1Department of Neurological Sciences, Rush-Presbyterian-St Luke's Medical Center, Rush University, Chicago, IL, USA. kkompoli@rush.edu
Neurology
|November 30, 2000
Abstract:
Questionnaire studies have found that parkinsonism worsens in women during the premenstrual period, when estrogen and progesterone levels are presumably at their nadir. To assess this patient-based observation and correlate motor signs with hormonal levels, the authors prospectively studied 10 menstruating women with PD in their "off" state, on 5 successive weeks. Although PD severity fluctuated during the study period, there was no significant correlation between the objective or subjective measures of parkinsonism and estrogen and progesterone levels.