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Intraductal Injection of LPS as a Mouse Model of Mastitis: Signaling Visualized via an NF-κB Reporter Transgenic

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Granulomatous mastitis in pregnancy.

J Goldberg¹, L Baute, L Storey

¹Department of Obstetrics and Gynecology, Jefferson Medical College, Philadelphia, Pennsylvania, USA.

Obstetrics and Gynecology

|November 30, 2000

Summary

Granulomatous mastitis in pregnancy is rare but treatable. Early corticosteroid treatment can effectively manage this benign breast condition and prevent unnecessary biopsies.

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Area of Science:

Obstetrics and Gynecology
Pathology
Dermatology

Background:

Granulomatous mastitis is a rare, benign breast condition often misdiagnosed as inflammatory breast cancer.
While reported in reproductive-age women, it is an unusual presentation during pregnancy.

Observation:

A 25-year-old pregnant woman presented with a large, tender breast mass at 17 weeks' gestation.
The mass did not respond to antibiotics or surgical drainage.

Findings:

Biopsy confirmed granulomatous mastitis.
Corticosteroid therapy led to improvement of the condition.
A postpartum recurrence also responded favorably to steroid treatment.

Implications:

Early clinical and histological diagnosis of granulomatous mastitis is crucial.
Prompt initiation of corticosteroid treatment may prevent extensive surgical interventions and disfigurement.
This case highlights the importance of considering granulomatous mastitis in pregnant patients with breast masses.