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Clear cell adenocarcinoma of the cervix associated with a rare genitourinary malformation
S Spörri1, H J Altermatt, E Dreher
1Department of Obstetrics and Gynecology, University of Bern, Bern, Switzerland. stefan.spoerri@insel.ch
Background:
Cervical adenocarcinoma and genitourinary malformations are relatively common disorders, yet their coexistence is rare.
Case:
A 49-year-old woman developed clear cell adenocarcinoma in the atretic hemicervix of a communicating uterus type 7 and had ipsilateral renal agenesis. Compared with the unaffected right hemicervix, only the tumor-involved glands of the atretic left hemicervix contained ciliated tuboendometrial cells. Four and a half years after radical hysterectomy and pelvic radiation, she showed no evidence of recurrence.
Conclusion:
In contrast to current opinion, communicating uteri type 7 are associated with ipsilateral renal agenesis. Our histologic findings support the hypothesis that tuboendometrial cells are the cells of origin for cervical clear-cell adenocarcinoma.