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Related Experiment Video

Updated: Jul 8, 2026

Measuring Motor Coordination in Mice
10:07

Measuring Motor Coordination in Mice

Published on: May 29, 2013

Longitudinal age-related changes in motor activities and spatial orientation in CD-1 mice.

C C Joyal1, S Beaudin, R Lalonde

  • 1Université de Montréal, Dépt. Psychologie, Québec, Canada.

Archives of Physiology and Biochemistry
|November 30, 2000
PubMed
Summary

Aging significantly impairs motor activity, exploration, and spatial memory in female mice. These age-related deficits suggest shared neurobiological pathways affecting motor and cognitive functions.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Behavioral Biology

Background:

  • Aging is associated with progressive declines in cognitive and motor functions.
  • Understanding the specific deficits and underlying mechanisms in aging is crucial for developing interventions.

Purpose of the Study:

  • To investigate the longitudinal effects of aging on exploration, motor coordination, and spatial orientation in female mice.
  • To identify potential correlations between motor and cognitive performance changes over time.

Main Methods:

  • Longitudinal assessment of female CD-1 mice over 19 months.
  • Behavioral testing included exploration (hole-board, T-maze), motor coordination (inclined grid, coat-hanger, round bridge), and spatial orientation (water maze).

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The Active Place Avoidance (APA) Test, an Effective, Versatile and Repeatable Spatial Learning Task for Mice

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Related Experiment Videos

Last Updated: Jul 8, 2026

Measuring Motor Coordination in Mice
10:07

Measuring Motor Coordination in Mice

Published on: May 29, 2013

Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration
07:46

Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration

Published on: June 18, 2018

The Active Place Avoidance (APA) Test, an Effective, Versatile and Repeatable Spatial Learning Task for Mice
06:03

The Active Place Avoidance (APA) Test, an Effective, Versatile and Repeatable Spatial Learning Task for Mice

Published on: February 16, 2024

Main Results:

  • Aging led to decreased motor activity and reduced exploration of novel stimuli.
  • Significant age-related deficits were observed in motor coordination tasks and spatial memory retention, but not acquisition.
  • Motor coordination performance correlated linearly with motor activity and exploration levels.

Conclusions:

  • Aging induces deficits in motor activity, exploration, and spatial memory retention in female mice.
  • The correlation between motor coordination and activity/exploration suggests shared neurobiological underpinnings for age-related functional decline.