Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Information processing efficiency in patients with multiple sclerosis.

C J Archibald1, J D Fisk

  • 1archibc.cadvision.com

Journal of Clinical and Experimental Neuropsychology
|November 30, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prodrome in relapsing-remitting and primary progressive multiple sclerosis.

European journal of neurology·2019
Same author

Rising incidence of psychiatric disorders before diagnosis of immune-mediated inflammatory disease.

Epidemiology and psychiatric sciences·2017
Same author

Lateralized microstructural changes in early-stage Parkinson's disease in anterior olfactory structures, but not in substantia nigra.

Journal of neurology·2017
Same author

Cholinesterases in normal and Alzheimer's disease primary olfactory gyrus.

Neuropathology and applied neurobiology·2017
Same author

Systematic review and meta-analysis of interventions for depression and anxiety in persons with multiple sclerosis.

Multiple sclerosis and related disorders·2016
Same author

Comorbidity is associated with pain-related activity limitations in multiple sclerosis.

Multiple sclerosis and related disorders·2015
Same journal

Stability and accuracy of specific learning disability diagnoses from childhood to young adulthood.

Journal of clinical and experimental neuropsychology·2026
Same journal

Performance validity test failure rates among neuropsychological outpatients clinically referred for persistent Long COVID cognitive symptoms following mild SARS-CoV-2 disease severity.

Journal of clinical and experimental neuropsychology·2026
Same journal

Correction.

Journal of clinical and experimental neuropsychology·2026
Same journal

A 50-year personal odyssey through the story of learning disabilities: from primary school to adult LD diagnoses.

Journal of clinical and experimental neuropsychology·2026
Same journal

The gut-brain axis in Alzheimer's and Parkinson's diseases: a systematic review of microbiota-derived biomarkers and novel therapeutic approaches.

Journal of clinical and experimental neuropsychology·2026
Same journal

Sex-specific associations between reproductive history and late-life cognitive outcomes.

Journal of clinical and experimental neuropsychology·2026
See all related articles

Multiple Sclerosis (MS) patients show slower information processing speed. Working memory deficits appear with disease progression, impacting new learning in MS.

Area of Science:

  • Neuroscience
  • Psychology
  • Neurology

Background:

  • Cognitive impairments are common in Multiple Sclerosis (MS).
  • Reduced information processing efficiency due to neural transmission issues is a proposed cause.
  • Existing cognitive tests may be confounded by perceptual-motor deficits.

Purpose of the Study:

  • To assess information processing speed and working memory capacity in mild to moderate MS patients.
  • To differentiate cognitive performance between MS subtypes and controls.
  • To identify the cognitive underpinnings of new learning impairments in MS.

Main Methods:

  • Utilized experimental psychology measures controlling for perceptual-motor abnormalities (Salthouse et al., 1991; Sternberg, 1966, 1969).
  • Assessed information processing speed and working memory capacity.

Related Experiment Videos

  • Compared performance of relapsing-remitting and secondary-progressive MS patients with neurologically intact controls.

    • Main Results:

    • MS patients reported more cognitive complaints than controls.
    • No significant differences in immediate memory span or word list learning were found between groups.
    • Both MS subtypes showed significantly slower information processing speed compared to controls.
    • Secondary-progressive MS patients exhibited an additional decrement in working memory capacity.
    • Depression, fatigue, and neurological disability did not explain performance differences.

    Conclusions:

    • Information processing speed may be impaired early in Multiple Sclerosis.
    • Working memory deficits may emerge with disease progression in MS.
    • Working memory impairments are likely responsible for difficulties in new learning observed in MS patients.