Related Experiment Videos
Fibroblast biology. Development and differentiation of synovial fibroblasts in arthritis
1UCL Centre for Rheumatology, London, UK. jo.edwards@ucl.ac.uk
Arthritis Research
|November 30, 2000
Abstract:
Synovial fibroblasts occur as two phenotypes--intimal and subintimal. The specialised intimal phenotype includes expression of uridine diphosphoglucose dehydrogenase (UDPGD), vascular cell adhesion molecule-1 (VCAM-1) and complement decay-accelerating factor (DAF). These gene products contribute to specialised functions relating to tissue movement and leucocyte traffic.