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New pharmacologic options for renal preservation.

S Garwood1

  • 1Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut, USA. susan.garwood@yale.edu

Anesthesiology Clinics of North America
|November 30, 2000
PubMed
Summary

Pharmacologic strategies for renal failure are evolving beyond hemodynamics to include cellular interactions. Newer approaches targeting cellular responses show promise for protecting kidneys from injury.

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Area of Science:

  • Nephrology
  • Pharmacology
  • Anesthesiology

Background:

  • Understanding renal failure pathophysiology guides renoprotective strategies.
  • Traditional focus on renal hemodynamics is expanding to include cellular mechanisms.
  • Cellular interactions play a role in amplifying and perpetuating kidney injury.

Purpose of the Study:

  • To review the evolution of renoprotective strategies.
  • To highlight the shift from hemodynamic to cellular targets.
  • To discuss emerging therapeutic approaches for renal protection.

Main Methods:

  • Review of current understanding of renal failure.
  • Analysis of pharmacologic renoprotective strategies.
  • Discussion of cellular mechanisms in renal injury.

Main Results:

  • Renal protection strategies are moving beyond vasoactive agents.
  • Therapeutic approaches targeting cellular response to injury are emerging.
  • Few cellular-targeting agents are in clinical use, but show promise.

Conclusions:

  • Emerging cellular-based renoprotective strategies offer a promising new direction.
  • A comprehensive approach considering both hemodynamics and cellular interactions is key.
  • Further research into cellular mechanisms could lead to novel treatments for renal failure.

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