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[Structural organization and evolution of t-complex in Mus genus]
L D Safronova1, I V Shustrova, A P Ryskov
1Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences, Moscow, Russia.
Genetika
|November 30, 2000
Summary
The mouse t complex, a group of genes on chromosome 17, shows variations across Mus species. A new hypothesis suggests all t haplotypes originated from a single ancestral chromosome 17 inversion.
Area of Science:
- Genetics
- Evolutionary Biology
- Molecular Biology
Context:
- The t complex in mice (Mus genus) involves a series of inversions on chromosome 17.
- It contains genes influencing transmission to offspring, particularly in heterozygous males.
- Structural variants (t haplotypes) are found in specific wild mouse populations.
Purpose:
- To review current data on the structure and evolution of the mouse t complex.
- To discuss existing hypotheses (vertical, horizontal, introgressive) regarding its origin.
- To propose a novel hypothesis integrating population genetics and molecular data.
Summary:
- The t complex, characterized by inversions on murine chromosome 17, exhibits genetic variations (t haplotypes) in four wild Mus species.
- Existing evolutionary hypotheses for the t complex include vertical, horizontal, and introgressive models.
- A new hypothesis posits a common ancestral chromosome 17 with a proximal inversion as the origin for all known t haplotypes, synthesizing vertical and horizontal models.
Impact:
- Provides a comprehensive overview of t complex evolution.
- Introduces a new, integrated hypothesis for the origin of t haplotypes.
- Advances understanding of genetic system evolution in wild mouse populations.