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In vitro tannin acantholysis.

S Brenner1, V Ruocco, E Ruocco

  • 1Department of Dermatology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel.

International Journal of Dermatology
|November 30, 2000
PubMed
Summary
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Tannic acid, a plant-derived compound, demonstrated significant acantholytic potential in vitro, suggesting a possible role in pemphigus pathogenesis. Its potency exceeds that of known drugs, with individual susceptibility varying.

Area of Science:

  • Dermatology
  • Cell Biology
  • Toxicology

Background:

  • Pemphigus, an autoimmune blistering disease, may be induced by exogenous factors like drugs.
  • Tannins, known for their biological activity, are investigated for their potential role in pemphigus.
  • Understanding the pathomechanism of pemphigus is crucial for developing targeted therapies.

Purpose of the Study:

  • To investigate the in vitro acantholytic potential of tannins.
  • To determine if tannins can induce changes similar to those seen in pemphigus.
  • To compare the acantholytic potency of tannins with known causative agents.

Main Methods:

  • Normal human breast skin explants were cultured for 3 days.
  • Explants were treated with varying concentrations of tannic acid (0.02–2.0 mM).

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  • Microscopic examination by three independent investigators in a blinded manner assessed acantholytic changes.

    • Main Results:

    • Tannic acid induced marked acantholytic changes, including suprabasal cleavage and intraepidermal acantholytic cells.
    • These effects were consistently observed at 1.0 and 2.0 mM tannic acid.
    • The effective concentrations were notably low, with significant inter-individual variability in explant response.

    Conclusions:

    • Tannins possess significant in vitro acantholytic potential, suggesting a possible role in pemphigus development.
    • Tannin's acantholytic potency appears greater than that of drugs like penicillamine and captopril.
    • Inter-individual differences in susceptibility to acantholysis may explain varying pemphigus risk.