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Related Experiment Videos

Basal ganglia involvement in memory-guided movement sequencing.

V Menon1, R T Anagnoson, G H Glover

  • 1Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305-5719, USA.

Neuroreport
|November 30, 2000
PubMed
Summary

The basal ganglia (BG) help sequence movements. This study shows BG, particularly the posterior putamen and globus pallidus (GP), are involved in working memory (WM) for motor tasks, modulating thalamic activity.

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Motor Control

Background:

  • The basal ganglia (BG) are crucial for motor planning and sequencing.
  • The role of BG in working memory (WM) remains unclear, despite prefrontal cortex involvement.
  • Understanding BG function in WM is essential for explaining complex motor behaviors.

Purpose of the Study:

  • To investigate the specific roles of different basal ganglia nuclei in memory-guided motor sequencing.
  • To explore the functional connectivity between BG and thalamus during WM-guided movements.
  • To provide fMRI evidence for BG involvement in WM-guided motor planning.

Main Methods:

  • Utilized a motor sequencing task with fMRI to measure brain activation.
  • Analyzed functional connectivity between BG nuclei and the thalamus.

Related Experiment Videos

  • Compared brain activity during memory-guided vs. non-guided movement conditions.

    • Main Results:

    • Observed significant activation in the dorsolateral prefrontal cortex (DLPFC), posterior putamen, and globus pallidus (GP).
    • Found a correlation between posterior putamen + GP activation and thalamic activation in the contralateral hemisphere during movement.
    • No significant activation differences were noted in the anterior putamen or caudate nucleus.

    Conclusions:

    • Provides the first fMRI evidence for basal ganglia modulating thalamic activity during WM-guided motor sequencing.
    • Suggests posterior putamen and GP play a role in maintaining WM representations for motor planning and temporal organization.
    • Highlights the contribution of BG to complex cognitive-motor tasks involving working memory.