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Updated: Oct 10, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Impact of Antibiotic Resistance on the Treatment of Gram-negative Sepsis
1Division of Infectious Disease, Brigham and Women's Hospital, and Harvard Medical School, PBB-A4, 15 Francis Street, Boston, MA 02115, USA. lbaden@partners.org
Abstract:
Resistance among gram-negative organisms has greatly complicated the care of the septic patient. An understanding of the likely source of infection, the epidemiologic risk of the patient being exposed to an antibiotic-resistant organism, and the specific vulnerabilities of the host are essential to the proper selection of empiric antimicrobial therapy. In this report, we discuss the epidemiology, antibiotic resistance mechanisms, microbiology, treatment strategies, and diagnostic and therapeutic innovations in the approach to the septic patient.
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