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Related Experiment Videos

Olive oils rich in natural catecholic phenols decrease isoprostane excretion in humans.

F Visioli1, D Caruso, C Galli

  • 1Institute of Pharmacological Sciences, Milan, Italy. francesco.visioli@unimi.it

Biochemical and Biophysical Research Communications
|November 30, 2000
PubMed
Summary
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Olive oil phenolics like hydroxytyrosol demonstrate antioxidant activity in humans. Consuming phenol-rich olive oil reduced oxidative stress biomarkers, showing a dose-dependent effect.

Area of Science:

  • Nutritional Science
  • Biochemistry
  • Human Physiology

Background:

  • Olive oil phenolics, including hydroxytyrosol and oleuropein aglycone, possess a unique orthodiphenolic structure.
  • Oxidative stress is implicated in various human health conditions.
  • Assessing the in vivo antioxidant capacity of dietary compounds is crucial for understanding their health benefits.

Purpose of the Study:

  • To evaluate the human antioxidant activity of olive oil phenolics, specifically hydroxytyrosol and oleuropein aglycone.
  • To determine the dose-dependent relationship between phenolic intake and oxidative stress markers.
  • To investigate the correlation between hydroxytyrosol metabolites and oxidative stress biomarkers.

Main Methods:

  • Human volunteers consumed olive oil with varying concentrations of phenolic extract.

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  • Phenolic extract composition was analyzed using gas-chromatography/mass spectrometry.
  • Urinary excretion of 8-iso-PGF(2alpha) (oxidative stress biomarker) and homovanillyl alcohol (HValc, hydroxytyrosol metabolite) was measured.

    • Main Results:

    • Phenol-rich olive oil consumption led to a dose-dependent decrease in urinary 8-iso-PGF(2alpha) excretion.
    • A significant negative correlation was observed between HValc and F(2)-isoprostanes excretion.
    • These findings indicate a reduction in oxidative stress associated with hydroxytyrosol and oleuropein aglycone intake.

    Conclusions:

    • Olive oil phenolics, hydroxytyrosol and oleuropein aglycone, exhibit significant antioxidant effects in humans.
    • Urinary 8-iso-PGF(2alpha) excretion is a reliable indicator of the in vivo antioxidant activity of these compounds.
    • The metabolite HValc may serve as a valuable biomarker for reflecting hydroxytyrosol's biological activity.