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Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
08:52

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Published on: May 27, 2011

Parainfluenza virus type 3 infections in hematopoetic stem cell transplant recipients: response to ribavirin therapy

S Chakrabarti1, K E Collingham, K Holder

  • 1Department of Haematology, Birmingham Heartlands Hospital, Birmingham, United Kingdom.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|November 30, 2000
PubMed

Insights

Hematopoietic stem cell transplant patients are at risk for parainfluenza virus (PIV) infections. Early ribavirin treatment showed a positive response in five patients with PIV 3 infection.

Area of Science:

  • Virology
  • Immunology
  • Hematology

Background:

  • Parainfluenza virus (PIV) poses a significant risk to hematopoietic stem cell transplant (HSCT) recipients.
  • Respiratory viral infections are a common complication in immunocompromised patients post-HSCT.

Purpose of the Study:

  • To evaluate the incidence of respiratory viral infections in HSCT recipients.
  • To describe the clinical course and outcomes of patients with PIV 3 infection treated with ribavirin.

Main Methods:

  • Prospective evaluation of 125 HSCT patients for respiratory viral infections.
  • Case series describing five patients with confirmed PIV 3 infection.

Main Results:

  • Five cases of PIV 3 infection were identified among the evaluated patients.
  • These patients received early treatment with ribavirin, and their responses were documented.

Conclusions:

  • PIV 3 infection is a relevant pathogen in HSCT recipients.
  • Early ribavirin intervention may be a beneficial treatment strategy for PIV 3 infection in this population.

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