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Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson's Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation

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Wolff-Parkinson-White Syndrome.

Sharma¹, O'Neill

¹Regional Cardiology Associates, 3941 J Street, Suite 260, Sacramento, CA 95819, USA.

Current Treatment Options in Cardiovascular Medicine

|November 30, 2000

Summary

Wolff-Parkinson-White syndrome patients face a lethal risk from atrial fibrillation. Catheter ablation offers a highly effective and safe treatment for accessory pathway conduction, with a 90-95% success rate.

Area of Science:

Cardiology
Electrophysiology

Background:

Atrial fibrillation in Wolff-Parkinson-White syndrome can be lethal, with a 4% lifetime risk of sudden death.
Recurrent cardiac arrhythmias contribute to significant morbidity in affected patients.

Purpose of the Study:

To highlight the efficacy and necessity of catheter ablation for Wolff-Parkinson-White syndrome.
To emphasize the management pathway for patients with this condition.

Main Methods:

Review of longitudinal natural history studies.
Analysis of catheter ablation therapy outcomes.
Comparison with pharmacologic and surgical therapies.

Main Results:

Catheter ablation demonstrates 90-95% efficacy in eliminating accessory pathway conduction.

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The procedure is associated with low morbidity rates.

Pharmacologic therapy is a secondary option for non-responders or those declining ablation.

Conclusions:

Catheter ablation is the preferred curative treatment for Wolff-Parkinson-White syndrome.
Early recognition and referral to an electrophysiologist are crucial for effective management.