Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Disorders of Sinus Function.

Mandel1, Jordan, Karagueuzian

  • 1The Division of Cardiology, Cedars-Sinai Medical Center, 8700 Beverly Blvd., West Hollywood, CA 90048-1865, USA.

Current Treatment Options in Cardiovascular Medicine
|November 30, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immediate reconstruction of the anal sphincter after fistulectomy in the management of complex anal fistulas.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2013
Same author

Effects of folliculin on acid-soluble plasma phosphorus in ducks.

Comptes rendus des seances de la Societe de biologie et de ses filiales·2010
Same author

Targeted Antiestrogens to Prevent Breast Cancer.

Trends in endocrinology and metabolism: TEM·2001
Same author

Causal implications of viscous damping in compressible fluid flows

Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics·2001
Same author

Asymptotic convergence rate of the EM algorithm for gaussian mixtures

Neural computation·2000
Same author

Symmetry breaking and dynamical independence in a multimode laser

Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics·2000
Same journal

An Update on the Role of Renal Artery Denervation in the Treatment of Hypertension.

Current treatment options in cardiovascular medicine·2026
Same journal

Advancements and Challenges in Contemporizing Care for Adult Patients with Congenital Heart Disease and Advanced Heart Failure: An Update on Application of Modern Heart Failure Technologies.

Current treatment options in cardiovascular medicine·2026
Same journal

Evolving Decongestion Strategies in the Management of Acute Heart Failure.

Current treatment options in cardiovascular medicine·2025
Same journal

Advanced Electroanatomic Mapping: Current and Emerging Approaches.

Current treatment options in cardiovascular medicine·2025
Same journal

Metabolic Reprogramming in Heart Failure: From Energy Starvation to Therapeutic Targets.

Current treatment options in cardiovascular medicine·2025
Same journal

Drug-Coated Balloons for Coronary Artery Disease: From Theory to Practice.

Current treatment options in cardiovascular medicine·2025
See all related articles

Sinus node dysfunction diagnosis can be challenging. While dual-chamber pacing may prevent atrial fibrillation, mortality remains high, especially with coexisting heart disease, necessitating individualized treatment.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Internal Medicine

Background:

  • Sinus node dysfunction (SND) is a prevalent condition with significant clinical impact, often posing diagnostic challenges.
  • Etiologies of SND are multifactorial, with potential roles for immunologic abnormalities.
  • Diagnosis may involve invasive electrophysiology studies, and treatment requires integrated medical therapy.

Purpose of the Study:

  • To review the diagnostic challenges and therapeutic strategies for sinus node dysfunction.
  • To evaluate the impact of different pacing methods on outcomes, including atrial fibrillation and mortality.
  • To discuss the long-term prognosis and individualized treatment approaches for SND.

Main Methods:

  • Review of clinical and electrophysiological findings in patients with sinus node dysfunction.

Related Experiment Videos

  • Analysis of treatment outcomes, including medical therapy and permanent pacing strategies.
  • Comparison of outcomes between different pacing modalities (dual-chamber vs. ventricular) and their impact on atrial fibrillation and embolic events.

    • Main Results:

    • Dual-chamber pacing may reduce the incidence of atrial fibrillation and systemic embolization compared to ventricular pacing.
    • Mortality in SND patients remains high, particularly with coexisting cardiovascular or valvular heart disease and congestive heart failure.
    • Survival rates are significantly lower in patients with sick sinus syndrome and congestive heart failure, with a high incidence of embolic events even with permanent pacing.

    Conclusions:

    • Treatment for sinus node dysfunction, especially pacing, should be individualized based on arrhythmia type and underlying conditions.
    • Anticoagulation is crucial for patients with bradycardia-tachycardia syndrome and sick sinus syndrome to prevent embolic events.
    • Despite advancements, the natural history of SND is not fully understood, and pacemaker therapy is often withheld in asymptomatic patients due to undefined risk factors and lack of reliable predictive measures.