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Related Experiment Videos

Cutaneous necrosis due to cetrimide application.

P J August

    British Medical Journal
    |January 11, 1975
    PubMed
    Summary

    Cetrimide, a quaternary ammonium compound, rarely causes necrosis. This report details a rare case of severe leg and foot necrosis in an elderly woman due to topical cetrimide powder application.

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    Area of Science:

    • Dermatology
    • Toxicology

    Background:

    • Quaternary ammonium compounds (QACs) are widely used antiseptics.
    • Necrosis from topical QACs, like cetrimide, is infrequently reported.

    Purpose of the Study:

    • To report a rare case of cutaneous necrosis.
    • To highlight potential adverse effects of topical cetrimide powder.

    Main Methods:

    • Case report of a 77-year-old female patient.
    • Clinical observation of cutaneous necrosis on the left foot and leg.
    • Review of topical application of cetrimide powder.

    Main Results:

    • The patient developed severe cutaneous necrosis of the left lower extremity.
    • Necrosis was attributed to the topical application of cetrimide powder.
    • The patient required a four-month hospitalization.

    Conclusions:

    • Topical cetrimide powder can cause severe cutaneous necrosis.
    • Healthcare professionals should be aware of this rare but serious adverse effect.
    • Judicious use of topical cetrimide is recommended.

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