Mechanical Approaches for Myocardial Angiogenesis

Because angiogenesis appears to be a fundamental mechanism associated with direct myocardial revascularization (DMR) procedures, it seems natural to combine the overall field of DMR with angiogenesis therapy. Such myocardial treatment strategy can thus be termed "mechanical approach for myocardial angiogenesis." In this article, we review the myocardial response to various ablative energy sources in order to explore data indicative for angiogenesis in response to mechanical myocardial injury, or by using hybrid approaches, combining energy sources with proangiogenic pharmacotherapy.