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Related Experiment Videos

The Angel Wings Das Devices for Atrial Septal Defect Closure.

Das1, Harrison, O'Laughlin

  • 1Cardiovascular Division, Box 508, University of Minnesota, 420 Delaware Street, SE, Minneapolis, MN 55455, USA. dasxx007@tc.umn.edu

Current Interventional Cardiology Reports
|November 30, 2000
PubMed
Summary

The Angel Wings device effectively closes atrial septal defects (ASDs) and patent foramen ovale (PFOs) with high success rates and minimal residual shunts. This innovative prosthesis demonstrated safety and efficacy in clinical trials, with no device-related deaths reported.

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Area of Science:

  • Cardiovascular Devices
  • Medical Engineering
  • Interventional Cardiology

Background:

  • Atrial septal defects (ASDs) and patent foramen ovale (PFOs) are common cardiac conditions requiring closure.
  • Existing closure devices have varying success rates and complication profiles.
  • The Angel Wings device offers a novel approach to percutaneous closure of these defects.

Purpose of the Study:

  • To evaluate the safety and efficacy of the Angel Wings device for ASD and PFO closure.
  • To assess the implantation success rates and incidence of residual shunts.
  • To report on device-related adverse events.

Main Methods:

  • The Angel Wings device, a nitinol-polyester prosthesis, was implanted in patients with ASDs and PFOs.
  • Implantation was performed using a customized delivery catheter.

Related Experiment Videos

  • Transthoracic echocardiography was used to assess residual shunts at 24 hours post-implantation.

    • Main Results:

    • High implantation success rates were observed: 92-94% for ASDs and 97-100% for PFOs.
    • In Phase II trials, 86% of ASD patients had minimal residual shunts (<1mm) at 24 hours.
    • No device-related deaths, embolization, or infective endocarditis were reported.

    Conclusions:

    • The Angel Wings device is a safe and effective option for percutaneous closure of ASDs and PFOs.
    • The device demonstrates high closure rates and a favorable safety profile.
    • Modified versions with improved features (circular disks, retrievability) are expected for future clinical use.