Related Experiment Videos
Imaging Angiogenesis with Three-Dimensional Microscopic Computed Tomography
B Kantor1, E L Ritman, D R Holmes
1Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Mayo Foundation, SMH 4523, 200 First Street SW, Rochester, MN 55905, USA. schwartzr@mayo.edu
Current Interventional Cardiology Reports
|November 30, 2000
Summary
Patients with advanced coronary artery disease need new treatments. Therapeutic angiogenesis, which induces new blood vessel growth, is a promising approach to improve blood flow and survival.
Area of Science:
- Cardiovascular Medicine
- Regenerative Medicine
- Molecular Biology
Background:
- Many patients with advanced coronary artery disease (CAD) experience persistent symptoms despite optimal medical and interventional therapies.
- There is a significant unmet need for novel anti-anginal treatments and strategies to enhance survival in this patient population.
Purpose of the Study:
- To explore therapeutic angiogenesis as a novel strategy for increasing blood flow to the ischemic myocardium.
- To review current and emerging methods for inducing therapeutic angiogenesis in the context of coronary artery disease.
Main Methods:
- Review of current literature on therapeutic angiogenesis and its application in advanced coronary artery disease.
- Discussion of methods including local angiogenic growth factor administration, gene therapy, and direct myocardial revascularization.
Main Results:
- Therapeutic angiogenesis represents an intriguing new approach to address myocardial ischemia.
- Existing and developing techniques show potential for inducing new blood vessel growth in the heart.
Conclusions:
- Therapeutic angiogenesis holds promise as an alternative anti-anginal therapy for patients with refractory symptoms.
- Ongoing basic and clinical research is crucial for advancing these novel therapeutics for improved patient outcomes.