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Therapeutic Angiogenesis Using Local Perivascular and Pericardial Delivery.

Laham1, Post, Sellke

  • 1Angiogenesis Research Center and Interventional Cardiology Section, Department of Medicine and Surgery, Harvard Medical School and Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA. rlaham@bidmc.harvard.edu

Current Interventional Cardiology Reports
|November 30, 2000
PubMed
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Therapeutic angiogenesis aims to grow new blood vessels for ischemic heart disease. Current delivery methods like local perivascular and pericardial delivery show promise for enhancing coronary artery bypass surgery and promoting collateral vessel growth.

Area of Science:

  • Cardiovascular Medicine
  • Regenerative Medicine
  • Molecular Biology

Background:

  • Therapeutic angiogenesis is a potential treatment for ischemic heart disease, aiming to restore blood flow by promoting new blood vessel growth.
  • Despite extensive research, clinical application remains theoretical due to incomplete understanding of angiogenesis mechanisms and optimal delivery strategies.
  • Key knowledge gaps include understanding adult collateralization, growth factor efficacy, and the balance between epicardial and intramyocardial neovascularization.

Purpose of the Study:

  • To review current data on local perivascular and pericardial delivery methods for therapeutic angiogenesis.
  • To evaluate the potential of these delivery strategies as adjuncts to coronary artery bypass surgery and in non-instrumented pericardial applications.
  • To discuss the theoretical advantages of these methods in affecting epicardial vessels and promoting collateral circulation.

Related Experiment Videos

Main Methods:

  • Review of existing literature on therapeutic angiogenesis and delivery modalities.
  • Analysis of data concerning local perivascular and pericardial delivery techniques.
  • Discussion of the role of angiogenic cytokines and delivery parameters.

Main Results:

  • Local perivascular and pericardial delivery strategies are discussed as viable options for therapeutic angiogenesis.
  • These methods may serve as adjuncts to coronary artery bypass surgery.
  • Potential exists for these strategies to promote epicardial feeding collaterals.

Conclusions:

  • Local perivascular and pericardial delivery methods offer promising avenues for therapeutic angiogenesis in ischemic heart disease.
  • Further research is needed to optimize cytokine selection, delivery, and duration for clinical success.
  • These approaches may enhance myocardial perfusion by promoting collateral vessel formation.