Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neuropsychiatric Systemic Lupus Erythematosus.

Navarrete1, Brey

  • 1Department of Medicine (Neurology), University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive--Mail Code 7883, San Antonio, TX 78229-3900, USA. brey@uthscsa.edu

Current Treatment Options in Neurology
|November 30, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Resistance against migrating ascaris suum larvae in pigs immunized with infective eggs or adult worm antigens.

Parasitology·2001
Same author

Zidovudine (ZDV) and Lamivudine (3TC) Combination Therapy for HIV Infection - A Review.

The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases·2000
Same author

Optimal strategies for sending information through A quantum channel

Physical review letters·2000
Same author

Boundary conditions and normal state for a vibrated granular fluid

Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics·2000
Same author

Variation in barnacle recruitment over small scales: larval predation by adults and maintenance of community pattern.

Journal of experimental marine biology and ecology·2000
Same author

Phase diagram of diluted magnetic semiconductor quantum wells

Physical review letters·2000
Same journal

Visual Impairment and Driving in Older Adults: A Narrative Review.

Current treatment options in neurology·2026
Same journal

Non-Cognitive Symptoms in Alzheimer's Disease and Their Likely Impact on Patient Outcomes. A Scoping Review.

Current treatment options in neurology·2026
Same journal

Update on the Treatment of Autonomic Disorders.

Current treatment options in neurology·2025
Same journal

Primary Progressive Aphasia Treatment: Current Treatment Options in Neurology Article Topic: Management of Primary Progressive Aphasia.

Current treatment options in neurology·2025
Same journal

Emerging Principles for Treating Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD).

Current treatment options in neurology·2025
Same journal

Diagnosis and Management of Progressive Corticobasal Syndrome.

Current treatment options in neurology·2025
See all related articles

Treating neuropsychiatric systemic lupus erythematosus (NPSLE) requires excluding secondary causes and diagnosing specific nervous system issues. Treatment depends on the manifestation and systemic disease activity, guiding symptomatic or aggressive therapies.

Area of Science:

  • Neurology
  • Rheumatology
  • Immunology

Background:

  • Neuropsychiatric systemic lupus erythematosus (NPSLE) presents diverse neurological and psychiatric symptoms.
  • Differentiating NPSLE manifestations from secondary causes like infection or medication side effects is critical.

Purpose of the Study:

  • To outline diagnostic and treatment strategies for NPSLE.
  • To emphasize the importance of excluding secondary causes before attributing symptoms to NPSLE.

Main Methods:

  • Diagnostic evaluation involves excluding secondary causes, assessing systemic lupus erythematosus (SLE) activity, and using neuroimaging, electroencephalography, cerebrospinal fluid analysis, nerve conduction studies, and serologic tests.
  • Systemic disease activity is monitored via complement levels, anti-dsDNA, CBC, and urinalysis.

Related Experiment Videos

Main Results:

  • Accurate diagnosis of specific NPSLE manifestations guides treatment decisions.
  • Symptomatic treatment is suitable for mild NPSLE symptoms without systemic disease flares.
  • High-dose glucocorticoids, potentially with cyclophosphamide, are indicated for severe NPSLE manifestations like psychosis or transverse myelopathy.

Conclusions:

  • Effective NPSLE management hinges on precise diagnosis and tailored treatment strategies.
  • Treatment intensity is dictated by the specific NPSLE manifestation and overall SLE disease activity.