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Double-stranded nucleic acids in liquid-crystalline dispersions as building blocks for cross-linked supramolecular
Y M Yevdokimov1, V I Salyanov, B V Mchedlischvili
1VA Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, Moscow.
Nucleosides, Nucleotides & Nucleic Acids
|November 30, 2000
Abstract:
Double-stranded DNA fixed in a cholesteric liquid-crystalline dispersion was used for generating an ordered supramolecular structure in the presence of anthracycline and copper (II) ions. The structure is stable in a water-salt solution and does not require poly(ethyleneglycol).The ordered network can be immobilized on the surface of a polymeric film, and may collapse in the presence of biologically and pharmacologically relevant compounds. Accordingly, the DNA-based liquid-crystalline network represents the basis to obtain novel highly sensitive biosensing units.