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Presence of apolipoprotein E epsilon4 allele in cerebral palsy
Meirelles Kalil Pessoa de Barr1, C J Rodrigues, T E de Barros
1Department of Orthopaedics, School of Medicine, University of São Paulo, Brazil. pebarros@netpoint.com.br
Abstract:
The apolipoprotein E gene, which is located on chromosome 19, has three alleles (epsilon2, epsilon3, and epsilon4). Several recent publications associate the presence of the apolipoprotein E epsilon4 allele with the occurrence of neurologic diseases, and consider it a risk factor for the development of central nervous system affections. A group of 40 patients with cerebral palsy was studied and compared to a control group of 40 subjects, and higher occurrence of the allele epsilon4 in the group of subjects with cerebral palsy was observed. A significantly higher risk of developing cerebral palsy was demonstrated among those subjects with the apolipoprotein E epsilon4 allele.
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