Contrast-enhanced three-dimensional MR angiography in the assessment of subclavian artery diseases
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Updated: Oct 10, 2026

Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques
Published on: June 11, 2019
M Cosottini1, V Zampa, P Petruzzi
1Department of Radiology, University of Pisa, Italy.
Insights
3D breath-hold contrast-enhanced MRA (CEMRA) accurately diagnoses subclavian artery issues, showing high agreement with digital subtraction angiography (DSA). This non-invasive technique offers excellent sensitivity and specificity for steno-occlusive disease and vascular anomalies.
Area of Science:
- Vascular Imaging
- Radiology
- Cardiovascular Diagnostics
Background:
- Subclavian artery pathology requires accurate diagnostic methods.
- Digital subtraction angiography (DSA) is invasive.
- Non-invasive imaging alternatives are needed.
Purpose of the Study:
- To evaluate the diagnostic value of 3D breath-hold contrast-enhanced MRA (CEMRA) for subclavian artery pathology.
- To compare CEMRA findings with DSA.
Main Methods:
- Prospective study of 50 patients with suspected subclavian artery pathology.
- CEMRA performed on a 1.5-T system with Gd-DTPA contrast.
- Multireader blinded analysis comparing CEMRA and DSA.
Main Results:
- CEMRA showed optimal agreement with DSA findings.
- Sensitivity and specificity for steno-occlusive disease: 90% and 95%.
- Sensitivity and specificity for vascular anomalies: 100% and 100%.
Conclusions:
- CEMRA is a non-invasive and robust technique for subclavian pathology imaging.
- CEMRA demonstrates high diagnostic performance.
- CEMRA can be a valuable alternative to DSA.
Abstract:
The purpose of this prospective study was to determine the potential diagnostic value of 3D breath-hold contrast-enhanced MRA (CEMRA) in the evaluation of subclavian artery pathology, and to compare CEMRA and digital subtraction angiography (DSA) findings. The study group included 50 patients with suspicion of subclavian artery pathology: 40 suspected steno-occlusive disease and 10 different vascular anomalies. The MRA examinations were performed on a 1.5-T system using fast 3D sequences. A fixed dose of 40 ml Gd-DTPA was administered at 2 ml/s after previous bolus tracking. Images were analyzed to assess: subclavian depiction; luminal changes; collateral branches; and feeders of arterial venous malformations (AVM). A multireader blinded fashion was used. The CEMRA revealed an optimal agreement with DSA findings in the different types of diseases. Sensitivity and specificity were 90 and 95%, respectively, in detecting steno-occlusive disease (including functional and arteritic stenoses), and 100 and 100%, respectively, in cases of vascular anomalies (dilation, kinking, anomalous origin and AVM). Contrast-enhanced MRA can be proposed as a non-invasive, robust technique for imaging subclavian pathologies with high diagnostic performance.
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