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Related Experiment Videos

Fetal microchimerism in primary biliary cirrhosis.

C Corpechot1, V Barbu, O Chazouillères

  • 1Service d'Hepato-Gastro-Entérologie, Hôpital Saint-Antoine, Paris, France. corpechot@st-antoine.inserm.fr

Journal of Hepatology
|November 30, 2000
PubMed
Summary

Fetal microchimerism, the presence of cells from a fetus in a mother, was not a major factor in primary biliary cirrhosis (PBC). However, it was linked to anticentromere antibodies in PBC patients.

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Area of Science:

  • Immunology
  • Hepatology
  • Genetics

Background:

  • Fetal microchimerism is implicated in scleroderma pathogenesis.
  • Primary biliary cirrhosis (PBC) shares similarities with scleroderma.

Purpose of the Study:

  • To investigate the role of fetal microchimerism in primary biliary cirrhosis (PBC).

Main Methods:

  • Quantitative nested polymerase chain reaction (PCR) was used.
  • Y-chromosome sequences were detected in blood and liver of PBC women and controls with male children.

Main Results:

  • Male microchimerism was detected in 45% of PBC women and 25% of controls in peripheral blood.
  • Microchimerism levels did not differ between PBC patients and controls in blood or liver.

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  • Microchimerism was more frequent in PBC patients with anticentromere antibodies (p=0.049).

    • Conclusions:

    • Fetal microchimerism does not appear to be a significant factor in most PBC cases.
    • An association between microchimerism and anticentromere antibodies suggests a potential role in specific PBC subgroups, possibly related to CREST syndrome or scleroderma.