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Related Experiment Videos

Pre-core mutant infections in the Canadian Inuit.

G Y Minuk1, P S Orr, R Brown

  • 1Liver Diseases Unit, University of Manitoba, Winnipeg, Canada.

Journal of Hepatology
|November 30, 2000
PubMed
Summary
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Hepatitis B virus (HBV) infections in Canadian Inuit are largely inactive. This study found a high prevalence of the HBV pre-core mutant variant in this population.

Area of Science:

  • Hepatology
  • Virology
  • Infectious Diseases

Background:

  • Previous studies suggested inactive chronic Hepatitis B virus (HBV) infections among Canadian Inuit.
  • This research aimed to confirm HBV inactivity and assess the prevalence of the HBV pre-core mutant variant in this population.

Purpose of the Study:

  • To confirm the inactive status of chronic Hepatitis B virus (HBV) infections in Canadian Inuit.
  • To determine the prevalence of the HBV pre-core mutant variant within this population.

Main Methods:

  • Sera were collected from selected residents in five remote Canadian Inuit communities.
  • Hepatitis B virus (HBV) serology, HBV-DNA, and pre-core mutant testing were conducted using commercial assays, PCR, and direct sequencing.

Main Results:

Related Experiment Videos

  • Of 176 participants, 38 (22%) were HBsAg positive and 16 (9.1%) anti-HBs positive.
  • Among HBsAg positive carriers (n=37), none were HBeAg positive, 97% were anti-HBe positive, and all had normal liver function tests.
  • HBV-DNA was detected in 81% of HBsAg positive carriers, with 87% of these harboring the pre-core mutant variant.

Conclusions:

  • The majority of Hepatitis B virus (HBV) infections in community-based Canadian Inuit are inactive.
  • The prevalence of the HBV pre-core mutant variant in this population is the highest reported to date.