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Updated: Aug 17, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
[Radiation-induced superficial fibrosis and TGF-alpha 1]
M Martin1, S Delanian, V Sivan
1Laboratoire de radiobiologie et d'étude du génome, DRR, DSV, CEA Saclay, Gif-sur-Yvette, France.
Abstract:
Radiation-induced fibrosis is a late sequela of both therapeutic and accidental irradiations, which has been described in various tissues, including the lung, liver, kidney and skin. This review presents different aspects of superficial radiation-induced fibrosis, such as clinical observations, histological changes, cellular and molecular regulations, and medical management. Recent evidence on the critical role played by TGF-beta 1 in the initiation, development and persistence of fibrosis are discussed, as well as the possibility that this cytokine may constitute a specific target for antifibrotic agents.
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