Related Experiment Video

Updated: Oct 10, 2026

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring
17:16

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Published on: December 9, 2010

Toxic metronidazole-induced MRI changes

C K Horlen1, C F Seifert, C S Malouf

  • 1School of Pharmacy, Texas Tech University Health Sciences Center, Lubbock 79430, USA.

The Annals of Pharmacotherapy
|December 1, 2000
PubMed
Abstract

Insights

Metronidazole accumulation in patients with liver dysfunction can cause central nervous system (CNS) and peripheral neuropathy. This case highlights MRI changes associated with metronidazole toxicity, emphasizing dose reduction in liver impairment.

Area of Science:

  • Neurology
  • Pharmacology
  • Radiology

Background:

  • Metronidazole is a commonly prescribed antibiotic.
  • Liver dysfunction can impair drug metabolism and increase the risk of toxicity.
  • Neurological complications associated with metronidazole are well-documented.

Observation:

  • A patient with cirrhosis and hepatitis C developed ataxia, disorientation, and peripheral neuropathy while on metronidazole therapy.
  • Magnetic resonance imaging (MRI) revealed characteristic signal changes in the brainstem and cerebellum after significant metronidazole accumulation.
  • Toxic serum metronidazole concentration was confirmed.

Findings:

  • This case demonstrates metronidazole-induced neurotoxicity, evidenced by clinical symptoms and specific MRI findings.
  • The observed MRI changes, including increased signal intensity in the cerebellar and brainstem regions, are consistent with metronidazole accumulation.
  • The patient's liver dysfunction likely contributed to the elevated and toxic serum levels of metronidazole.

Implications:

  • This case underscores the importance of cautious metronidazole dosing in patients with hepatic impairment to prevent neurotoxicity.
  • Healthcare providers should be vigilant for neurological symptoms in patients with liver dysfunction receiving metronidazole.
  • Awareness of these potential MRI changes can aid in the diagnosis and management of metronidazole-induced neurotoxicity.

More Related Videos

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

Related Concept Videos

Imaging Studies I: CT and MRI01:14

Imaging Studies I: CT and MRI

Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
Drug Toxicity: Risk factors01:24

Drug Toxicity: Risk factors

Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...