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Related Experiment Videos

Seizure possibly associated with fluvoxamine.

K Y Kim1, J M Craig, J M Hawley

  • 1Department of Psychiatric Medicine, School of Medicine, University of Virginia, Charlottesville, USA. kyekim726@aol.com

The Annals of Pharmacotherapy
|December 1, 2000
PubMed
Summary
This summary is machine-generated.

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Therapeutic doses of fluvoxamine may trigger seizures, even in patients with a history of head trauma. Clinicians should exercise caution, particularly with patients having prior seizure history.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Psychiatry

Background:

  • Selective serotonin-reuptake inhibitors (SSRIs) like fluvoxamine are commonly prescribed for psychiatric conditions.
  • While generally considered safe, SSRIs can have potential adverse effects, including seizures.
  • A history of seizures or head trauma may increase seizure risk in patients taking SSRIs.

Observation:

  • A patient with schizoaffective disorder and a history of seizures experienced a breakthrough seizure while on therapeutic doses of fluvoxamine.
  • The patient was also receiving anticonvulsants for his mood disorder.
  • No other underlying medical conditions were identified as the cause of the seizure.

Findings:

  • The seizure occurred at a therapeutic dosage of fluvoxamine, suggesting it may not be solely an overdose phenomenon.

Related Experiment Videos

  • Seizures associated with fluvoxamine have been reported more frequently with overdose.
  • The patient's seizure risk factors included a past history of seizures and head trauma.

    • Implications:

    • Clinicians should be aware of the potential for fluvoxamine-induced seizures, even at therapeutic doses.
    • Caution is advised when prescribing fluvoxamine to patients with a history of seizures or head trauma.
    • This case highlights the importance of considering all potential contributing factors, including concurrent psychotropic medications, when evaluating seizures in patients treated with SSRIs.