[Pathogenesis of coronary disease]

Area of Science:

• Cardiovascular Science
• Metabolic Disease Research
• Genetics and Public Health

Background:

• Overweight (OW) is a well-established risk factor for coronary heart disease (CHD).
• OW contributes to the pathogenesis of CHD by inducing insulin resistance (IR), leading to diabetes, hypertension, and lipid disorders.
• Recent research highlights OW's role in endothelial dysfunction through elevated serum fatty acids, initiating molecular events crucial to CHD progression.

Purpose of the Study:

• To investigate the underlying causes of the high incidence of overweight and its associated health risks.
• To explore the genetic predisposition and environmental adaptation factors contributing to overweight.

Main Methods:

• Literature review of existing studies on overweight, coronary heart disease, insulin resistance, and endothelial dysfunction.
• Analysis of genetic factors and their interaction with environmental changes in the context of overweight.

Main Results:

• Overweight is strongly linked to the development of metabolic disorders and cardiovascular complications.
• Insulin resistance and endothelial dysfunction are key mechanisms through which overweight impacts CHD.
• Genetic factors may limit the population's adaptive capacity to environmental changes, contributing to the prevalence of overweight.

Conclusions:

• Understanding the roots of overweight is crucial for developing effective prevention and management strategies for CHD.
• Genetic predisposition plays a significant role in the modern epidemic of overweight.
• Further research into gene-environment interactions is needed to address the rising incidence of overweight and its associated diseases.