Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Reverse remodeling by surgery--fact or fiction?].

H R Zerkowski1, M T Grapow, A Todorov

  • 1Universitätsklinik für Herz- und Thoraxchirurgie, Kantonsspital Basel.

Zeitschrift Fur Kardiologie
|December 1, 2000
PubMed
Summary

Despite advances in heart failure treatment, mortality remains high. Surgical options like ventricular assist devices (VADs) show promise as a bridge to transplantation, with ongoing trials comparing them to medical therapy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The transCampus Metabolic Training Programme Explores the Link of SARS-CoV-2 Virus to Metabolic Disease.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2021
Same author

Improved tendon healing using bFGF, BMP-12 and TGFβ1 in a rat model.

European cells & materials·2018
Same author

Novel insights into transcriptional dysregulation in colorectal cancer.

Neoplasma·2018
Same author

Low osmolality and shear stress during liposuction impair cell viability in autologous fat grafting.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2017
Same author

[Reverse remodeling by surgery - fact or fiction?].

Zeitschrift fur Kardiologie·2016
Same author

Increased gene expression of the cardiac endothelin system in obese mice.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2014

Area of Science:

  • Cardiology
  • Cardiac Surgery
  • Medical Technology

Background:

  • Chronic heart failure (CHF) mortality remains high in developed nations.
  • Heart transplantation is limited by donor organ availability.
  • Several surgical alternatives exist for end-stage heart failure.

Purpose of the Study:

  • To review current surgical alternatives to heart transplantation for end-stage heart failure.
  • To evaluate the efficacy and outcomes of dynamic cardiomyoplasty (CMP), mitral valve reconstruction, partial left ventricular reduction (PLVR), and ventricular assist devices (VADs).
  • To highlight an ongoing randomized trial comparing VADs with medical therapy for NYHA class IV patients.

Main Methods:

  • Literature review and summary of existing studies on surgical interventions for heart failure.
  • Discussion of reported outcomes for CMP, mitral valve reconstruction, PLVR, and VADs.
  • Description of a U.S. randomized trial comparing VADs to medical therapy.

Main Results:

  • Dynamic cardiomyoplasty (CMP) has not shown improved survival or physiological benefits in dilated cardiomyopathy.
  • Mitral valve reconstruction demonstrates promising results.
  • Partial left ventricular reduction (PLVR) shows immediate cardiac function improvement, but long-term effects are unknown.
  • Ventricular assist devices (VADs) are effective as a bridge to transplantation, but not approved for permanent use.

Conclusions:

  • Surgical interventions offer alternatives for heart failure patients ineligible for transplantation.
  • VADs are a critical temporary solution, with ongoing research to define their role against medical therapy.
  • Further research is needed to establish long-term outcomes for procedures like PLVR.

Related Experiment Videos