Prolactin and beta-endorphin serum elevations after ECT in manic patients

¹Fatima Jinnah Medical College, Punjab University, Lahore, Pakistan.

|December 1, 2000

Abstract

Objective:

Alterations in prolactin and beta-endorphin serum levels after ECT are well-established findings in depression. The present study focuses on electroconvulsive therapy (ECT) response patterns of the mentioned parameters in patients suffering from acute mania.

Method:

Following the first three ECTs of a treatment series in 19 patients diagnosed according to DSM-III-R criteria as suffering from mania, blood samples were drawn before, and 20, 30 and 40 minutes after ECT. Serum prolactin and beta-endorphin levels were established in order to gain information about the effects of ECT on different neurotransmitter systems.

Results:

A significant transient increase in serum prolactin after ECT was found. Furthermore, in females but not males, delta(max)prolactin diminished over the course of treatment as prolactin baseline levels increased. beta-endorphin levels showed a stable transient increase after ECT stimulus regardless from sex or treatment.

Conclusion:

The reported findings reflect those established in depression. This suggests that they are epiphenomenal to ECT.

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Prolactin and beta-endorphin serum elevations after ECT in manic patients

Objective:

Method:

Results:

Conclusion:

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