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Immunological treatments for autism.

S Gupta1

  • 1Division of Basic and Clinical Immunology, Medical Sciences I, University of California, Irvine 92697, USA. sgupta@uci.edu

Journal of Autism and Developmental Disorders
|December 1, 2000
PubMed
Summary

Children with autism exhibit immune system dysregulation, involving both deficiencies and excesses in immune responses. Genetic factors within the major histocompatibility complex may also play a role in autism, influencing treatment strategies.

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Area of Science:

  • Immunology
  • Neuroscience
  • Genetics

Background:

  • Autism spectrum disorder (ASD) is associated with significant alterations in immune system function.
  • Observed immune changes in children with autism include both deficiencies and excesses in immune responses, indicating dysregulation.
  • The major histocompatibility complex (MHC), crucial for immune regulation, has been implicated in ASD pathogenesis.

Purpose of the Study:

  • To review and summarize immunological abnormalities observed in children with autism.
  • To analyze and discuss various biological treatment modalities applied to children with autism based on immunological findings.

Main Methods:

  • Literature review of studies investigating immune responses in autism.
  • Analysis of genetic associations, particularly within the major histocompatibility complex.
  • Synthesis of data on immunological abnormalities and their correlation with therapeutic interventions.

Main Results:

  • Children with autism display a pattern of immune dysregulation, characterized by imbalances in immune components.
  • Evidence suggests a link between specific genes in the major histocompatibility complex and the susceptibility to or manifestation of autism.
  • Various biological therapies have been explored, targeting the identified immunological abnormalities.

Conclusions:

  • Immune system dysregulation is a notable feature in autism spectrum disorder.
  • Genetic factors, including those in the MHC, are likely involved in the complex etiology of autism.
  • Understanding these immunological aspects is critical for developing and refining biological treatment approaches for autism.

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