Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Feedback control of intercellular signalling in development.

M Freeman1

  • 1MRC Laboratory of Molecular Biology, Cambridge, UK. MF1@mrc-lmb.cam.ac.uk

Nature
|December 1, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Narrowing the care and treatment gap through a human resources for mental health plan: Key considerations.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
Same author

Upskilling clinicians in compression therapy for leg ulcers - "Planet Compression Day" initiative.

Journal of vascular nursing : official publication of the Society for Peripheral Vascular Nursing·2025
Same author

First Demonstration of Improved Fusion Yield with Increased Compression through Reduced Adiabat in Inertial Confinement Fusion Experiments at the National Ignition Facility.

Physical review letters·2025
Same author

Optically multiplexed neutron time-of-flight technique for inertial confinement fusion.

The Review of scientific instruments·2024
Same author

Spot size measurement of a deuterium-tritium dense plasma focus using neutron radiography.

The Review of scientific instruments·2024
Same author

Observations and properties of the first laboratory fusion experiment to exceed a target gain of unity.

Physical review. E·2024
Same journal

Six ways to put the public at the heart of science and policy.

Nature·2026
Same journal

The complex truth about trust in science.

Nature·2026
Same journal

Have people stopped trusting science? The data tell a surprising story.

Nature·2026
Same journal

How FAIR data are helping to build trust in science.

Nature·2026
Same journal

Scientists should recognize their own political biases to build public trust.

Nature·2026
Same journal

Harmonizing standards and resources for the medical genome.

Nature·2026
See all related articles

Precise cell fate regulation during development relies on feedback loops in cell signaling. Disruptions in these essential communication pathways can lead to developmental diseases.

Area of Science:

  • Developmental Biology
  • Cell Signaling
  • Molecular Biology

Background:

  • Precise control of intercellular communication is crucial for regulating cell fate during animal development.
  • Errors in cell fate determination can lead to severe developmental abnormalities and diseases.
  • Dynamic regulation of developmental signaling pathways is essential for accurate biological outcomes.

Purpose of the Study:

  • To investigate the role of feedback loops in the dynamic regulation of intercellular communication during animal development.
  • To understand how positive and negative feedback mechanisms contribute to the precision, robustness, and versatility of developmental signals.
  • To explore the consequences of feedback loop failure in developmental signaling.

Main Methods:

  • Analysis of existing literature on developmental signaling and feedback mechanisms.

Related Experiment Videos

  • Review of experimental studies investigating intercellular communication in model organisms.
  • Computational modeling of signaling pathways with feedback loops (if applicable, based on abstract).

    • Main Results:

    • Positive and negative feedback loops are critical for the dynamic regulation of developmental signaling.
    • These feedback interactions enhance the precision, robustness, and versatility of intercellular signals.
    • Dysregulation or failure of feedback mechanisms can result in developmental diseases.

    Conclusions:

    • Feedback loops are fundamental to achieving precise cell fate control during development.
    • Understanding these regulatory mechanisms is key to preventing and treating developmental disorders.
    • The study underscores the importance of maintaining the integrity of signaling feedback pathways.