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Related Experiment Videos

Ringtail in suckling Munich Wistar Fromter rats: a histopathologic study.

L Crippa1, A Gobbi, R M Ceruti

  • 1Novuspharma, Monza, Italy.

Comparative Medicine
|December 1, 2000
PubMed
Summary

Ringtail, a tail condition in rodents, is characterized by epidermal hyperplasia, hyperkeratosis, and acanthosis. These histologic findings suggest primary epidermal changes are key to understanding ringtail pathogenesis.

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Area of Science:

  • Veterinary Pathology
  • Rodent Health
  • Dermatology

Background:

  • Ringtail is a tail pathology in rodents, often linked to low humidity.
  • Previous studies have not detailed the histopathologic aspects of ringtail.
  • Contributing factors may include diet, genetics, temperature, and hydration.

Purpose of the Study:

  • To provide a detailed histopathologic description of ringtail.
  • To investigate the etiopathogenesis of ringtail in rodents.

Main Methods:

  • Histologic examination of tail tissues from 12 affected suckling Munich Wistar Fromter (MWF) rats.
  • Gross examination of affected tails.

Main Results:

  • All affected rats exhibited epidermal hyperplasia with orthokeratotic and parakeratotic hyperkeratosis and acanthosis.

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  • Dermal examination revealed numerous dilated vessels, some thrombosed in severe cases.
  • Severe cases showed dermal hemorrhages and epidermal coagulative necrosis.

    • Conclusions:

    • Epidermal acanthosis and hyperkeratosis appear to be primary events in ringtail development.
    • Further research should focus on factors inducing these epidermal changes to elucidate ringtail's cause.