Related Experiment Video
Updated: Jul 15, 2026
07:26
Systematic Assessment of Mammalian Skull Specimens for Dental and Temporomandibular Joint Pathology
Published on: August 22, 2022
An audit of the Yorkshire Regional Cleft Database
1Orthodontic Department, Leeds Dental Institute, Worsley Building, Clarendon Way, Leeds LS2 9LU, UK.
Journal of Orthodontics
|December 2, 2000
Summary
The Yorkshire orofacial cleft database significantly under-reports cleft lip and isolated cleft palate cases, affecting prevalence data. Data collection improvements are needed for accurate cleft birth statistics.
Area of Science:
- Medical Informatics
- Public Health
- Pediatric Surgery
Background:
- Accurate data on orofacial clefts is crucial for understanding prevalence and guiding public health interventions.
- Regional databases are valuable tools for epidemiological surveillance of birth defects.
- The Yorkshire regional orofacial cleft database aimed to capture comprehensive data on affected infants.
Purpose of the Study:
- To evaluate the accuracy and completeness of the Yorkshire regional orofacial cleft database.
- To compare computer-based database records with locally collated surgical event data.
- To identify discrepancies in the reporting of orofacial cleft cases.
Main Methods:
- Retrospective comparison of two data sources: the regional database and local surgical records.
- Inclusion criteria: infants born between 1994-1995 with orofacial clefts (excluding submucous cleft palate).
- Analysis of ascertainment rates for different cleft subtypes and reporting variability across cleft units.
Main Results:
- Only 62% of identified orofacial cleft cases were present in the database.
- Significant under-reporting observed for cleft lip (42% ascertainment) and isolated cleft palate (50% ascertainment).
- Reporting rates varied widely among individual cleft treatment centers (43-85%).
Conclusions:
- The Yorkshire regional orofacial cleft database underestimates the true prevalence of orofacial clefts, particularly cleft lip and isolated cleft palate.
- The relative frequency of combined cleft lip and palate cases appears exaggerated due to under-reporting of other subtypes.
- Improvements in data collection methodologies are essential to enhance the validity and reliability of the database for epidemiological research and clinical practice.
More Related Videos
10:23Three-Dimensional Cephalometric Landmark Annotation Demonstration on Human Cone Beam Computed Tomography Scans
Published on: September 8, 2023
08:03Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
Published on: November 4, 2025
Related Concept Videos
01:17Karyotyping
Describing the number and physical features of chromosomes can reveal abnormalities that underlie genetic diseases. This description is facilitated by special staining techniques that produce a particular banding pattern on each chromosome. State-of-the-art techniques make this approach even more powerful, enabling the detection of individual genes that cause disease.A Simple Chromosome Staining Technique Provides Valuable Scientific InsightSome genetic diseases can be detected by looking at...
01:17Karyotyping
Describing the number and physical features of chromosomes can reveal abnormalities that underlie genetic diseases. This description is facilitated by special staining techniques that produce a particular banding pattern on each chromosome. State-of-the-art techniques make this approach even more powerful, enabling the detection of individual genes that cause disease.A Simple Chromosome Staining Technique Provides Valuable Scientific InsightSome genetic diseases can be detected by looking at...
01:18Classification of Bones
The bones of the human skeletal system are of varied shapes, sizes, and functions. They can be classified based on their shape and function into four major classes: long bones, short bones, flat bones, and irregular bones. Some classifications include a fifth type, the sesamoid bones, as a separate class, whereas others categorize them under short bones.
Long and Short Bones
The appendicular skeleton, particularly the upper and lower limbs, is primarily made of long and short bones. The long...
Long and Short Bones
The appendicular skeleton, particularly the upper and lower limbs, is primarily made of long and short bones. The long...
01:14Cranial Bones: Superior and Posterior View
The superior view of the cranium shows the frontal and paired parietal bones.
The frontal bone is the single bone that forms the forehead. At its anterior midline, between the eyebrows, there is a slight depression called the glabella. The frontal bone also forms the supraorbital margin of the orbit. Near the middle of this margin is the supraorbital foramen, the opening that provides passage for a sensory nerve to the forehead. The frontal bone is thickened just above each supraorbital margin,...
The frontal bone is the single bone that forms the forehead. At its anterior midline, between the eyebrows, there is a slight depression called the glabella. The frontal bone also forms the supraorbital margin of the orbit. Near the middle of this margin is the supraorbital foramen, the opening that provides passage for a sensory nerve to the forehead. The frontal bone is thickened just above each supraorbital margin,...
01:27Cranial Bones: Lateral View
The lateral view of the cranium is dominated by temporal, sphenoid, and ethmoid bones.
The temporal bone forms the lower lateral side of the skull. The temporal bone is subdivided into several regions. The flattened upper portion is the squamous portion of the temporal bone. Below this area and projecting anteriorly is the zygomatic process of the temporal bone, which forms the posterior portion of the zygomatic arch. Posteriorly is the mastoid portion of the temporal bone. Projecting...
The temporal bone forms the lower lateral side of the skull. The temporal bone is subdivided into several regions. The flattened upper portion is the squamous portion of the temporal bone. Below this area and projecting anteriorly is the zygomatic process of the temporal bone, which forms the posterior portion of the zygomatic arch. Posteriorly is the mastoid portion of the temporal bone. Projecting...
01:22Bone Marrow Sampling and Transplants
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...