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Papillary glioneuronal tumor.

¹Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA. praysor@cesmtp.ccf.org

Archives of Pathology & Laboratory Medicine

|December 2, 2000

Summary

This study details a rare papillary glioneuronal tumor in an 18-year-old male, presenting with headaches and vision issues. The tumor, resected successfully, exhibited mixed glial and neural components with a pseudopapillary pattern.

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Area of Science:

Neuro-oncology
Central Nervous System Pathology
Neoplastic Disease

Background:

Mixed glioneuronal tumors, including gangliogliomas and dysembryoplastic neuroepithelial tumors, are established central nervous system (CNS) lesions.
Recent literature has highlighted unusual variants, such as the papillary glioneuronal tumor.
This case expands the spectrum of recognized mixed glioneuronal neoplasms.

Observation:

An 18-year-old male presented with headaches and visual disturbances.
Imaging revealed a large cystic neoplasm in the left parieto-occipital lobe with peripheral enhancement.
The patient underwent gross total tumor resection.

Findings:

Histological examination showed a tumor composed of glial (GFAP-positive) and neural (synaptophysin-positive) components.
A focal pseudopapillary architectural pattern was observed, with papillae lined by glial cells and intervening neural elements.
Low proliferative activity (MIB-1 index 1.1%) and absence of necrosis or significant vascular proliferation were noted. p53 immunoreactivity was negative.

Implications:

This case contributes to the growing body of evidence for the existence of papillary glioneuronal tumors as a distinct entity.
Further research into the molecular and clinical characteristics of these rare tumors is warranted.
Understanding these unique CNS neoplasms aids in accurate diagnosis and patient management.

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