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HLA-Ig Based Artificial Antigen Presenting Cells for Efficient ex vivo Expansion of Human CTL
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Artificial antigen-presenting cells as a tool to exploit the immune 'synapse'

B Prakken1, M Wauben, D Genini

  • 1Department of Pediatrics, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093-0663, USA.

Nature Medicine
|December 2, 2000
PubMed

Recent progress in molecular medicine has provided important tools to identify antigen-specific T cells. In most cases, the approach is based on oligomeric combinations of recombinant major histocompatibility complex-peptide complexes fixed to various rigid supports available for binding by the T-cell receptor. These tools have greatly increased our insight into mechanisms of immune responses mediated by CD8+ T cells. Examples of the diverse fields of application for this technology include immunization, viral infections and oral tolerance induction.

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